A New Clerodane Diterpenoid Isolated from Propolis
نویسنده
چکیده
A physiologically active substance has been isolated from Brazilian propolis and charac terized as a new clerodane diterpenoid, as indicated by human hepatocellular carcinoma HuH 13 cell cytotoxicity assays. This compound inhibited growth of the hepatoma cells at a concentration around 10 [ig/ml and arrested the tumor cells at S phase as revealed by flow cytometry. A t higher concentrations it exerted lethal damage. The compound showed cyto toxicity on human lung carcinoma HLC-2, HeLa, KB and rat W 3Y cells, whereas human diploid foreskin and primary rabbit kidney cells were less affected.
منابع مشابه
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تاریخ انتشار 2013